About Peroxisomal acyl-coenzyme A oxidase 3
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) is a protein
from Homo sapiens identified by UniProt accession
O15254, 700 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Peroxisomal acyl-coenzyme A oxidase 3 |
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| UniProt accession | O15254 |
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| Gene | ACOX3 |
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| Organism | Homo sapiens |
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| Length | 700 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (66)
Diseases linked to this target (Open Targets).
- low grade glioma · score 0.18
- hemorrhoid · score 0.16
- body height · score 0.15
- carpal tunnel syndrome · score 0.05
- blood protein measurement · score 0.05
- Cataract-microcornea syndrome · score 0.05
- hereditary hyperferritinemia with congenital cataracts · score 0.05
- early-onset non-syndromic cataract · score 0.05
- Cataract with Y-shaped suture opacities · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15254-F1 | alphafold | PREDICTED | 94.17 | — |
Amino-acid sequence (700 residues)
MASTVEGGDT ALLPEFPRGP LDAYRARASF SWKELALFTE GEGMLRFKKT IFSALENDPL FARSPGADLS LEKYRELNFL RCKRIFEYDF LSVEDMFKSP LKVPALIQCL GMYDSSLAAK YLLHSLVFGS AVYSSGSERH LTYIQKIFRM EIFGCFALTE LSHGSNTKAI RTTAHYDPAT EEFIIHSPDF EAAKFWVGNM GKTATHAVVF AKLCVPGDQC HGLHPFIVQI RDPKTLLPMP GVMVGDIGKK LGQNGLDNGF AMFHKVRVPR QSLLNRMGDV TPEGTYVSPF KDVRQRFGAS LGSLSSGRVS IVSLAILNLK LAVAIALRFS ATRRQFGPTE EEEIPVLEYP MQQWRLLPYL AAVYALDHFS KSLFLDLVEL QRGLASGDRS ARQAELGREI HALASASKPL ASWTTQQGIQ ECREACGGHG YLAMNRLGVL RDDNDPNCTY EGDNNILLQQ TSNYLLGLLA HQVHDGACFR SPLKSVDFLD AYPGILDQKF EVSSVADCLD SAVALAAYKW LVCYLLRETY QKLNQEKRSG SSDFEARNKC QVSHGRPLAL AFVELTVVQR FHEHVHQPSV PPSLRAVLGR LSALYALWSL SRHAALLYRG GYFSGEQAGE VLESAVLALC SQLKDDAVAL VDVIAPPDFV LDSPIGRADG ELYKNLWGAV LQESKVLERA SWWPEFSVNK PVIGSLKSKL
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