About Nephrocystin-1
Nephrocystin-1 (NPHP1) is a protein
from Homo sapiens identified by UniProt accession
O15259, 732 residues long.
MolForge cross-references it against 0 known binders and
292 disease associations.
Target properties
| Protein name | Nephrocystin-1 |
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| UniProt accession | O15259 |
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| Gene | NPHP1 |
|---|
| Organism | Homo sapiens |
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| Length | 732 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (292)
Diseases linked to this target (Open Targets).
- nephronophthisis 1 · score 0.81
- Joubert syndrome with renal defect · score 0.78
- Senior-Loken syndrome 1 · score 0.75
- nephronophthisis · score 0.70
- Senior-Loken syndrome · score 0.66
- Joubert syndrome · score 0.57
- Nephronophthisis · score 0.53
- genetic disorder · score 0.49
- Joubert syndrome and related disorders · score 0.46
- Bardet-Biedl syndrome · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15259-F1 | alphafold | PREDICTED | 75.87 | — |
Amino-acid sequence (732 residues)
MLARRQRDPL QALRRRNQEL KQQVDSLLSE SQLKEALEPN KRQHIYQRCI QLKQAIDENK NALQKLSKAD ESAPVANYNQ RKEEEHTLLD KLTQQLQGLA VTISRENITE VGAPTEEEEE SESEDSEDSG GEEEDAEEEE EEKEENESHK WSTGEEYIAV GDFTAQQVGD LTFKKGEILL VIEKKPDGWW IAKDAKGNEG LVPRTYLEPY SEEEEGQESS EEGSEEDVEA VDETADGAEV KQRTDPHWSA VQKAISEAGI FCLVNHVSFC YLIVLMRNRM ETVEDTNGSE TGFRAWNVQS RGRIFLVSKP VLQINTVDVL TTMGAIPAGF RPSTLSQLLE EGNQFRANYF LQPELMPSQL AFRDLMWDAT EGTIRSRPSR ISLILTLWSC KMIPLPGMSI QVLSRHVRLC LFDGNKVLSN IHTVRATWQP KKPKTWTFSP QVTRILPCLL DGDCFIRSNS ASPDLGILFE LGISYIRNST GERGELSCGW VFLKLFDASG VPIPAKTYEL FLNGGTPYEK GIEVDPSISR RAHGSVFYQI MTMRRQPQLL VKLRSLNRRS RNVLSLLPET LIGNMCSIHL LIFYRQILGD VLLKDRMSLQ STDLISHPML ATFPMLLEQP DVMDALRSSW AGKESTLKRS EKRDKEFLKS TFLLVYHDCV LPLLHSTRLP PFRWAEEETE TARWKVITDF LKQNQENQGA LQALLSPDGV HEPFDLSEQT YDFLGEMRKN AV
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