Defensin beta 4A (DEFB4A)

About Defensin beta 4A

Defensin beta 4A (DEFB4A) is a protein from Homo sapiens identified by UniProt accession O15263, 64 residues long. MolForge cross-references it against 0 known binders and 308 disease associations.

Target properties

Protein name	Defensin beta 4A
UniProt accession	O15263
Gene	DEFB4A
Organism	Homo sapiens
Length	64 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (308)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.15
chronic obstructive pulmonary disease · score 0.10
psoriasis · score 0.10
Immunodeficiency due to a late component of complements deficiency · score 0.09
infect · score 0.09
infection · score 0.09
ulcerative colitis · score 0.08
inflammatory bowel disease · score 0.08
pulmonary tuberculosis · score 0.08
immunodeficiency 28 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15263-F1	alphafold	PREDICTED	78.00	—

Amino-acid sequence (64 residues)

MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI GTCGLPGTKC CKKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards