Mitogen-activated protein kinase 13 (MAPK13)

About Mitogen-activated protein kinase 13

Mitogen-activated protein kinase 13 (MAPK13) is a protein from Homo sapiens identified by UniProt accession O15264, 365 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	Mitogen-activated protein kinase 13
UniProt accession	O15264
Gene	MAPK13
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (144)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.29
blood protein measurement · score 0.28
neurodegenerative disease · score 0.26
glioblastoma multiforme · score 0.25
breast adenocarcinoma · score 0.25
cutaneous melanoma · score 0.23
neuroinflammatory disorder · score 0.23
attention deficit hyperactivity disorder · score 0.12
antisocial behaviour measurement · score 0.12
substance abuse · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15264-F1	alphafold	PREDICTED	89.05	—

Amino-acid sequence (365 residues)

MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards