Short stature homeobox protein (SHOX)

About Short stature homeobox protein

Short stature homeobox protein (SHOX) is a protein from Homo sapiens identified by UniProt accession O15266, 292 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Short stature homeobox protein
UniProt accession	O15266
Gene	SHOX
Organism	Homo sapiens
Length	292 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

Leri-Weill dyschondrosteosis · score 0.79
Langer mesomelic dysplasia · score 0.76
Léri-Weill dyschondrosteosis · score 0.74
SHOX-related short stature · score 0.71
body height · score 0.57
neurodegenerative disease · score 0.33
FEV change measurement · score 0.15
BMI-adjusted waist circumference · score 0.10
appendicular lean mass · score 0.09
connective tissue disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15266-F1	alphafold	PREDICTED	62.45	—

Amino-acid sequence (292 residues)

MEELTAFVSK SFDQKSKDGN GGGGGGGGKK DSITYREVLE SGLARSRELG TSDSSLQDIT EGGGHCPVHL FKDHVDNDKE KLKEFGTARV AEGIYECKEK REDVKSEDED GQTKLKQRRS RTNFTLEQLN ELERLFDETH YPDAFMREEL SQRLGLSEAR VQVWFQNRRA KCRKQENQMH KGVILGTANH LDACRVAPYV NMGALRMPFQ QVQAQLQLEG VAHAHPHLHP HLAAHAPYLM FPPPPFGLPI ASLAESASAA AVVAAAAKSN SKNSSIADLR LKARKHAEAL GL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards