About Telethonin
Telethonin (TCAP) is a protein
from Homo sapiens identified by UniProt accession
O15273, 167 residues long.
MolForge cross-references it against 0 known binders and
267 disease associations.
Target properties
| Protein name | Telethonin |
|---|
| UniProt accession | O15273 |
|---|
| Gene | TCAP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 167 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (267)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy 25 · score 0.78
- autosomal recessive limb-girdle muscular dystrophy type 2G · score 0.74
- limb-girdle muscular dystrophy · score 0.63
- dilated cardiomyopathy · score 0.57
- familial hypertrophic cardiomyopathy · score 0.55
- Abnormality of the cardiovascular system · score 0.51
- autosomal recessive limb-girdle muscular dystrophy · score 0.46
- Abnormality of the musculature · score 0.44
- familial isolated dilated cardiomyopathy · score 0.38
- hypertrophic cardiomyopathy · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15273-F1 | alphafold | PREDICTED | 79.04 | — |
Amino-acid sequence (167 residues)
MATSELSCEV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHQQGQCQVL VQRSPWLMMR MGILGRGLQE YQLPYQRVLP LPIFTPAKMG ATKEEREDTP IQLQELLALE TALGGQCVDR QEVAEITKQL PPVVPVSKPG ALRRSLSRSM SQEAQRG
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