About Fanconi anemia group G protein
Fanconi anemia group G protein (FANCG) is a protein
from Homo sapiens identified by UniProt accession
O15287, 622 residues long.
MolForge cross-references it against 0 known binders and
231 disease associations.
Target properties
| Protein name | Fanconi anemia group G protein |
|---|
| UniProt accession | O15287 |
|---|
| Gene | FANCG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 622 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (231)
Diseases linked to this target (Open Targets).
- Fanconi anemia complementation group G · score 0.81
- Fanconi anemia · score 0.76
- acute myeloid leukemia · score 0.54
- myelodysplastic syndrome · score 0.46
- leukemia · score 0.46
- colorectal adenocarcinoma · score 0.37
- lung carcinoma · score 0.37
- prostate carcinoma · score 0.37
- hearing loss · score 0.37
- head and neck malignant neoplasia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15287-F1 | alphafold | PREDICTED | 83.14 | — |
Amino-acid sequence (622 residues)
MSRQTTSVGS SCLDLWREKN DRLVRQAKVA QNSGLTLRRQ QLAQDALEGL RGLLHSLQGL PAAVPVLPLE LTVTCNFIIL RASLAQGFTE DQAQDIQRSL ERVLETQEQQ GPRLEQGLRE LWDSVLRASC LLPELLSALH RLVGLQAALW LSADRLGDLA LLLETLNGSQ SGASKDLLLL LKTWSPPAEE LDAPLTLQDA QGLKDVLLTA FAYRQGLQEL ITGNPDKALS SLHEAASGLC PRPVLVQVYT ALGSCHRKMG NPQRALLYLV AALKEGSAWG PPLLEASRLY QQLGDTTAEL ESLELLVEAL NVPCSSKAPQ FLIEVELLLP PPDLASPLHC GTQSQTKHIL ASRCLQTGRA GDAAEHYLDL LALLLDSSEP RFSPPPSPPG PCMPEVFLEA AVALIQAGRA QDALTLCEEL LSRTSSLLPK MSRLWEDARK GTKELPYCPL WVSATHLLQG QAWVQLGAQK VAISEFSRCL ELLFRATPEE KEQGAAFNCE QGCKSDAALQ QLRAAALISR GLEWVASGQD TKALQDFLLS VQMCPGNRDT YFHLLQTLKR LDRRDEATAL WWRLEAQTKG SHEDALWSLP LYLESYLSWI RPSDRDAFLE EFRTSLPKSC DL
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