About Protein phosphatase 1D
Protein phosphatase 1D (PPM1D) is a protein
from Homo sapiens identified by UniProt accession
O15297, 605 residues long.
MolForge cross-references it against 0 known binders and
370 disease associations.
Target properties
| Protein name | Protein phosphatase 1D |
|---|
| UniProt accession | O15297 |
|---|
| Gene | PPM1D |
|---|
| Organism | Homo sapiens |
|---|
| Length | 605 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (370)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with gastrointestinal difficulties and high pain threshold · score 0.74
- hereditary breast carcinoma · score 0.60
- genetic disorder · score 0.52
- neurodegenerative disease · score 0.51
- ovarian carcinoma · score 0.48
- breast carcinoma · score 0.44
- ovarian cancer · score 0.44
- malignant glioma · score 0.37
- colorectal adenocarcinoma · score 0.37
- syndromic intellectual disability · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15297-F1 | alphafold | PREDICTED | 67.89 | — |
Amino-acid sequence (605 residues)
MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG GEVSGKGPAV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ RMLRADNTSA IVICISPEVD NQGNFTNEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK SLEEDPWPRV NSKDHIPALV RSNAFSENFL EVSAEIAREN VQGVVIPSKD PEPLEENCAK ALTLRIHDSL NNSLPIGLVP TNSTNTVMDQ KNLKMSTPGQ MKAQEIERTP PTNFKRTLEE SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK TVCVC
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