Apoptosis regulatory protein Siva (SIVA1)

About Apoptosis regulatory protein Siva

Apoptosis regulatory protein Siva (SIVA1) is a protein from Homo sapiens identified by UniProt accession O15304, 175 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.

Target properties

Protein name	Apoptosis regulatory protein Siva
UniProt accession	O15304
Gene	SIVA1
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (67)

Diseases linked to this target (Open Targets).

breast carcinoma · score 0.15
forced expiratory volume · score 0.15
endometrial endometrioid carcinoma · score 0.13
endometrial carcinoma · score 0.13
peak expiratory flow · score 0.12
breast cancer · score 0.08
neoplasm · score 0.06
early-onset non-syndromic cataract · score 0.06
isolated ectopia lentis · score 0.06
MODY · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15304-F1	alphafold	PREDICTED	75.87	—

Amino-acid sequence (175 residues)

MPKRSCPFAD VAPLQLKVRV SQRELSRGVC AERYSQEVFE KTKRLLFLGA QAYLDHVWDE GCAVVHLPES PKPGPTGAPR AARGQMLIGP DGRLIRSLGQ ASEADPSGVA SIACSSCVRA VDGKAVCGQC ERALCGQCVR TCWGCGSVAC TLCGLVDCSD MYEKVLCTSC AMFET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards