About Phosphomannomutase 2
Phosphomannomutase 2 (PMM2) is a protein
from Homo sapiens identified by UniProt accession
O15305, 246 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Phosphomannomutase 2 |
|---|
| UniProt accession | O15305 |
|---|
| Gene | PMM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 246 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (154)
Diseases linked to this target (Open Targets).
- PMM2-congenital disorder of glycosylation · score 0.87
- congenital disorder of glycosylation · score 0.58
- SRD5A3-congenital disorder of glycosylation · score 0.55
- genetic disorder · score 0.54
- cerebellar ataxia · score 0.48
- isolated cerebellar hypoplasia/agenesis · score 0.48
- congenital disorder of glycosylation type I · score 0.45
- Intellectual disability · score 0.43
- cerebral palsy · score 0.42
- Poor speech · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15305-F1 | alphafold | PREDICTED | 96.43 | — |
Amino-acid sequence (246 residues)
MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI CELLFS
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