DNA repair protein RAD51 homolog 2 (RAD51B)

About DNA repair protein RAD51 homolog 2

DNA repair protein RAD51 homolog 2 (RAD51B) is a protein from Homo sapiens identified by UniProt accession O15315, 384 residues long. MolForge cross-references it against 0 known binders and 285 disease associations.

Target properties

Protein name	DNA repair protein RAD51 homolog 2
UniProt accession	O15315
Gene	RAD51B
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (285)

Diseases linked to this target (Open Targets).

cancer · score 0.59
platelet count · score 0.49
mean corpuscular volume · score 0.49
mean platelet volume · score 0.48
breast carcinoma · score 0.47
erythrocyte count · score 0.46
prostate carcinoma · score 0.46
body height · score 0.46
mean corpuscular hemoglobin · score 0.45
asthma · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15315-F1	alphafold	PREDICTED	78.90	—

Amino-acid sequence (384 residues)

MGSKKLKRVG LSQELCDRLS RHQILTCQDF LCLSPLELMK VTGLSYRGVH ELLCMVSRAC APKMQTAYGI KAQRSADFSP AFLSTTLSAL DEALHGGVAC GSLTEITGPP GCGKTQFCIM MSILATLPTN MGGLEGAVVY IDTESAFSAE RLVEIAESRF PRYFNTEEKL LLTSSKVHLY RELTCDEVLQ RIESLEEEII SKGIKLVILD SVASVVRKEF DAQLQGNLKE RNKFLAREAS SLKYLAEEFS IPVILTNQIT THLSGALASQ ADLVSPADDL SLSEGTSGSS CVIAALGNTW SHSVNTRLIL QYLDSERRQI LIAKSPLAPF TSFVYTIKEE GLVLQETTFC SVTQAELNWA PEILPPQPPE QLGLQMCHHT QLIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards