About DNA-directed RNA polymerase III subunit RPC7
DNA-directed RNA polymerase III subunit RPC7 (POLR3G) is a protein
from Homo sapiens identified by UniProt accession
O15318, 223 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerase III subunit RPC7 |
|---|
| UniProt accession | O15318 |
|---|
| Gene | POLR3G |
|---|
| Organism | Homo sapiens |
|---|
| Length | 223 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- self reported educational attainment · score 0.13
- intelligence · score 0.12
- autism · score 0.11
- Snoring · score 0.11
- insulin like growth factor measurement · score 0.11
- IGF-1 measurement · score 0.11
- cancer · score 0.09
- schizophrenia · score 0.09
- diastolic blood pressure · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15318-F1 | alphafold | PREDICTED | 67.31 | — |
Amino-acid sequence (223 residues)
MAGNKGRGRA AYTFNIEAVG FSKGEKLPDV VLKPPPLFPD TDYKPVPLKT GEGEEYMLAL KQELRETMKR MPYFIETPEE RQDIERYSKR YMKVYKEEWI PDWRRLPREM MPRNKCKKAG PKPKKAKDAG KGTPLTNTED VLKKMEELEK RGDGEKSDEE NEEKEGSKEK SKEGDDDDDD DAAEQEEYDE EEQEEENDYI NSYFEDGDDF GADSDDNMDE ATY
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