Chondroadherin (CHAD)

About Chondroadherin

Chondroadherin (CHAD) is a protein from Homo sapiens identified by UniProt accession O15335, 359 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Chondroadherin
UniProt accession	O15335
Gene	CHAD
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.14
body height · score 0.13
hepatocellular carcinoma · score 0.06
melorheostosis with osteopoikilosis · score 0.05
hyperostosis corticalis generalisata · score 0.05
gnathodiaphyseal dysplasia · score 0.04
Eiken syndrome · score 0.04
hip dysplasia, Beukes type · score 0.04
autosomal dominant osteosclerosis, Worth type · score 0.04
autosomal recessive osteopetrosis 6 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15335-F1	alphafold	PREDICTED	92.84	—

Amino-acid sequence (359 residues)

MVRPMLLLSL GLLAGLLPAL AACPQNCHCH SDLQHVICDK VGLQKIPKVS EKTKLLNLQR NNFPVLAANS FRAMPNLVSL HLQHCQIREV AAGAFRGLKQ LIYLYLSHND IRVLRAGAFD DLTELTYLYL DHNKVTELPR GLLSPLVNLF ILQLNNNKIR ELRAGAFQGA KDLRWLYLSE NALSSLQPGA LDDVENLAKF HVDRNQLSSY PSAALSKLRV VEELKLSHNP LKSIPDNAFQ SFGRYLETLW LDNTNLEKFS DGAFLGVTTL KHVHLENNRL NQLPSNFPFD SLETLALTNN PWKCTCQLRG LRRWLEAKAS RPDATCASPA KFKGQHIRDT DAFRSCKFPT KRSKKAGRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards