V-type proton ATPase subunit e 1 (ATP6V0E1)

About V-type proton ATPase subunit e 1

V-type proton ATPase subunit e 1 (ATP6V0E1) is a protein from Homo sapiens identified by UniProt accession O15342, 81 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	V-type proton ATPase subunit e 1
UniProt accession	O15342
Gene	ATP6V0E1
Organism	Homo sapiens
Length	81 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

multiple myeloma · score 0.21
breast adenocarcinoma · score 0.21
thyroid gland adenocarcinoma · score 0.18
colorectal carcinoma · score 0.15
appendicular lean mass · score 0.12
body mass index · score 0.07
base metabolic rate measurement · score 0.05
Varicose veins · score 0.03
mean corpuscular volume · score 0.02
amyotrophic lateral sclerosis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15342-F1	alphafold	PREDICTED	92.88	—

Amino-acid sequence (81 residues)

MAYHGLTVPL IVMSVFWGFV GFLVPWFIPK GPNRGVIITM LVTCSVCCYL FWLIAILAQL NPLFGPQLKN ETIWYLKYHW P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards