About E3 ubiquitin-protein ligase Midline-1
E3 ubiquitin-protein ligase Midline-1 (MID1) is a protein
from Homo sapiens identified by UniProt accession
O15344, 667 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase Midline-1 |
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| UniProt accession | O15344 |
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| Gene | MID1 |
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| Organism | Homo sapiens |
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| Length | 667 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (151)
Diseases linked to this target (Open Targets).
- X-linked Opitz G/BBB syndrome · score 0.81
- Opitz G/BBB syndrome · score 0.66
- genetic disorder · score 0.48
- Dandy-Walker syndrome · score 0.34
- Agenesis of corpus callosum · score 0.12
- Abnormal facial shape · score 0.12
- Clinodactyly of the 5th finger · score 0.12
- Low-set ears · score 0.12
- Hypertelorism · score 0.12
- diabetic nephropathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15344-F1 | alphafold | PREDICTED | 86.25 | — |
Amino-acid sequence (667 residues)
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES ITAFQCPTCR HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MTSAEKVLCQ FCDQDPAQDA VKTCVTCEVS YCDECLKATH PNKKPFTGHR LIEPIPDSHI RGLMCLEHED EKVNMYCVTD DQLICALCKL VGRHRDHQVA ALSERYDKLK QNLESNLTNL IKRNTELETL LAKLIQTCQH VEVNASRQEA KLTEECDLLI EIIQQRRQII GTKIKEGKVM RLRKLAQQIA NCKQCIERSA SLISQAEHSL KENDHARFLQ TAKNITERVS MATASSQVLI PEINLNDTFD TFALDFSREK KLLECLDYLT APNPPTIREE LCTASYDTIT VHWTSDDEFS VVSYELQYTI FTGQANVVSL CNSADSWMIV PNIKQNHYTV HGLQSGTKYI FMVKAINQAG SRSSEPGKLK TNSQPFKLDP KSAHRKLKVS HDNLTVERDE SSSKKSHTPE RFTSQGSYGV AGNVFIDSGR HYWEVVISGS TWYAIGLAYK SAPKHEWIGK NSASWALCRC NNNWVVRHNS KEIPIEPAPH LRRVGILLDY DNGSIAFYDA LNSIHLYTFD VAFAQPVCPT FTVWNKCLTI ITGLPIPDHL DCTEQLP
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