About High mobility group protein B3
High mobility group protein B3 (HMGB3) is a protein
from Homo sapiens identified by UniProt accession
O15347, 200 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | High mobility group protein B3 |
|---|
| UniProt accession | O15347 |
|---|
| Gene | HMGB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 200 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (185)
Diseases linked to this target (Open Targets).
- X-linked colobomatous microphthalmia-microcephaly-intellectual disability-short stature syndrome · score 0.45
- neurodegenerative disease · score 0.45
- syndromic microphthalmia · score 0.33
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- breast cancer · score 0.10
- non-small cell lung carcinoma · score 0.08
- gonorrhea · score 0.08
- Blackfan-Diamond anemia · score 0.08
- calf circumference measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15347-F1 | alphafold | PREDICTED | 80.04 | — |
Amino-acid sequence (200 residues)
MAKGDPKKPK GKMSAYAFFV QTCREEHKKK NPEVPVNFAE FSKKCSERWK TMSGKEKSKF DEMAKADKVR YDREMKDYGP AKGGKKKKDP NAPKRPPSGF FLFCSEFRPK IKSTNPGISI GDVAKKLGEM WNNLNDSEKQ PYITKAAKLK EKYEKDVADY KSKGKFDGAK GPAKVARKKV EEEDEEEEEE EEEEEEEEDE
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