About Tumor protein p73
Tumor protein p73 (TP73) is a protein
from Homo sapiens identified by UniProt accession
O15350, 636 residues long.
MolForge cross-references it against 0 known binders and
299 disease associations.
Target properties
| Protein name | Tumor protein p73 |
|---|
| UniProt accession | O15350 |
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| Gene | TP73 |
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| Organism | Homo sapiens |
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| Length | 636 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (299)
Diseases linked to this target (Open Targets).
- ciliary dyskinesia, primary, 47, and lissencephaly · score 0.71
- neurodegenerative disease · score 0.53
- acute myeloid leukemia · score 0.40
- small cell lung carcinoma · score 0.30
- ovarian cancer · score 0.29
- lung adenocarcinoma · score 0.29
- gastric adenocarcinoma · score 0.29
- breast adenocarcinoma · score 0.29
- endometrial cancer · score 0.28
- urinary bladder cancer · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15350-F1 | alphafold | PREDICTED | 65.20 | — |
Amino-acid sequence (636 residues)
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH
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