About Forkhead box protein N1
Forkhead box protein N1 (FOXN1) is a protein
from Homo sapiens identified by UniProt accession
O15353, 648 residues long.
MolForge cross-references it against 0 known binders and
572 disease associations.
Target properties
| Protein name | Forkhead box protein N1 |
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| UniProt accession | O15353 |
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| Gene | FOXN1 |
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| Organism | Homo sapiens |
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| Length | 648 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (572)
Diseases linked to this target (Open Targets).
- T-cell immunodeficiency, congenital alopecia, and nail dystrophy · score 0.79
- T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant · score 0.71
- Alymphoid cystic thymic dysgenesis · score 0.68
- Thymic aplasia · score 0.51
- Nezelof syndrome · score 0.51
- T-B+ severe combined immunodeficiency · score 0.46
- Aplasia of the thymus · score 0.27
- Relative macrocephaly · score 0.27
- autism · score 0.26
- tonsillectomy risk measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15353-F1 | alphafold | PREDICTED | 53.73 | — |
Amino-acid sequence (648 residues)
MVSLPPPQSD VTLPGPTRLE GERQGDLMQA PGLPGSPAPQ SKHAGFSCSS FVSDGPPERT PSLPPHSPRI ASPGPEQVQG HCPAGPGPGP FRLSPSDKYP GFGFEEAAAS SPGRFLKGSH APFHPYKRPF HEDVFPEAET TLALKGHSFK TPGPLEAFEE IPVDVAEAEA FLPGFSAEAW CNGLPYPSQE HGPQVLGSEV KVKPPVLESG AGMFCYQPPL QHMYCSSQPP FHQYSPGGGS YPIPYLGSSH YQYQRMAPQA STDGHQPLFP KPIYSYSILI FMALKNSKTG SLPVSEIYNF MTEHFPYFKT APDGWKNSVR HNLSLNKCFE KVENKSGSSS RKGCLWALNP AKIDKMQEEL QKWKRKDPIA VRKSMAKPEE LDSLIGDKRE KLGSPLLGCP PPGLSGSGPI RPLAPPAGLS PPLHSLHPAP GPIPGKNPLQ DLLMGHTPSC YGQTYLHLSP GLAPPGPPQP LFPQPDGHLE LRAQPGTPQD SPLPAHTPPS HSAKLLAEPS PARTMHDTLL PDGDLGTDLD AINPSLTDFD FQGNLWEQLK DDSLALDPLV LVTSSPTSSS MPPPQPPPHC FPPGPCLTET GSGAGDLAAP GSGGSGALGD LHLTTLYSAF MELEPTPPTA PAGPSVYLSP SSKPVALA
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