About Prosaposin receptor GPR37
Prosaposin receptor GPR37 (GPR37) is a protein
from Homo sapiens identified by UniProt accession
O15354, 613 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Prosaposin receptor GPR37 |
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| UniProt accession | O15354 |
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| Gene | GPR37 |
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| Organism | Homo sapiens |
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| Length | 613 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (105)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.32
- mean corpuscular volume · score 0.29
- neurofibrillary tangles measurement · score 0.29
- mean corpuscular hemoglobin · score 0.27
- glioblastoma multiforme · score 0.25
- ovarian cancer · score 0.25
- eosinophil count · score 0.24
- mean corpuscular hemoglobin concentration · score 0.21
- chronic lymphocytic leukemia · score 0.18
- nevus count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15354-F1 | alphafold | PREDICTED | 61.89 | — |
Amino-acid sequence (613 residues)
MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ RRGRDAWGPG NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR GAEASAAGPP GPPTRPPGPW RWKGARGQEP SETLGRGNPT ALQLFLQISE EEEKGPRGAG ISGRSQEQSV KTVPGASDLF YWPRRAGKLQ GSHHKPLSKT ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS TNRRVRLKNP FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGRAPAERCI IKISPDLPDT IYVLALTYDS ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKACTRGN KRQIQLESQM NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF KSCVTPVLLF CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR REMSTFASVG THC
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