About Protein phosphatase 1G
Protein phosphatase 1G (PPM1G) is a protein
from Homo sapiens identified by UniProt accession
O15355, 546 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Protein phosphatase 1G |
|---|
| UniProt accession | O15355 |
|---|
| Gene | PPM1G |
|---|
| Organism | Homo sapiens |
|---|
| Length | 546 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- triglyceride measurement · score 0.20
- glucose measurement · score 0.19
- body mass index · score 0.19
- diabetes mellitus · score 0.16
- hematocrit · score 0.16
- serum metabolite measurement · score 0.16
- cancer · score 0.16
- sex hormone-binding globulin measurement · score 0.15
- Crohn's disease · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15355-F1 | alphafold | PREDICTED | 73.07 | — |
Amino-acid sequence (546 residues)
MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGGGTGEE PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE AEEDDEEEEE EMMVPGMEGK EEPGSDSGTT AVVALIRGKQ LIVANAGDSR CVVSEAGKAL DMSYDHKPED EVELARIKNA GGKVTMDGRV NGGLNLSRAI GDHFYKRNKN LPPEEQMISA LPDIKVLTLT DDHEFMVIAC DGIWNVMSSQ EVVDFIQSKI SQRDENGELR LLSSIVEELL DQCLAPDTSG DGTGCDNMTC IIICFKPRNT AELQPESGKR KLEEVLSTEG AEENGNSDKK KKAKRD
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