About Eukaryotic translation initiation factor 3 subunit D
Eukaryotic translation initiation factor 3 subunit D (EIF3D) is a protein
from Homo sapiens identified by UniProt accession
O15371, 548 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 3 subunit D |
|---|
| UniProt accession | O15371 |
|---|
| Gene | EIF3D |
|---|
| Organism | Homo sapiens |
|---|
| Length | 548 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.16
- pancreatic adenocarcinoma · score 0.16
- neoplasm · score 0.09
- renal cell carcinoma · score 0.08
- lung adenocarcinoma · score 0.04
- reticulocyte measurement · score 0.04
- mean corpuscular volume · score 0.04
- gonorrhea · score 0.04
- body mass index · score 0.04
- infection · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15371-F1 | alphafold | PREDICTED | 82.71 | — |
Amino-acid sequence (548 residues)
MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS SQFGGGSQYA YFHEEDESSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ ILPKSAKQKE RERIRLQKKF QKQFGVRQKW DQKSQKPRDS SVEVRSDWEV KEEMDFPQLM KMRYLEVSEP QDIECCGALE YYDKAFDRIT TRSEKPLRSI KRIFHTVTTT DDPVIRKLAK TQGNVFATDA ILATLMSCTR SVYSWDIVVQ RVGSKLFFDK RDNSDFDLLT VSETANEPPQ DEGNSFNSPR NLAMEATYIN HNFSQQCLRM GKERYNFPNP NPFVEDDMDK NEIASVAYRY RRWKLGDDID LIVRCEHDGV MTGANGEVSF INIKTLNEWD SRHCNGVDWR QKLDSQRGAV IATELKNNSY KLARWTCCAL LAGSEYLKLG YVSRYHVKDS SRHVILGTQQ FKPNEFASQI NLSVENAWGI LRCVIDICMK LEEGKYLILK DPNKQVIRVY SLPDGTFSSD EDEEEEEEEE EEEEEEET
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