About Probable monocarboxylate transporter 5
Probable monocarboxylate transporter 5 (SLC16A4) is a protein
from Homo sapiens identified by UniProt accession
O15374, 487 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | Probable monocarboxylate transporter 5 |
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| UniProt accession | O15374 |
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| Gene | SLC16A4 |
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| Organism | Homo sapiens |
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| Length | 487 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- mean reticulocyte volume · score 0.12
- neutrophil count · score 0.12
- mean corpuscular volume · score 0.11
- adolescent idiopathic scoliosis · score 0.10
- cancer · score 0.08
- neoplasm · score 0.07
- non-small cell lung carcinoma · score 0.05
- mucinous carcinoma · score 0.04
- hypouricemia, renal, 2 · score 0.03
- hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15374-F1 | alphafold | PREDICTED | 79.70 | — |
Amino-acid sequence (487 residues)
MLKREGKVQP YTKTLDGGWG WMIVIHFFLV NVFVMGMTKT FAIFFVVFQE EFEGTSEQIG WIGSIMSSLR FCAGPLVAII CDILGEKTTS ILGAFVVTGG YLISSWATSI PFLCVTMGLL PGLGSAFLYQ VAAVVTTKYF KKRLALSTAI ARSGMGLTFL LAPFTKFLID LYDWTGALIL FGAIALNLVP SSMLLRPIHI KSENNSGIKD KGSSLSAHGP EAHATETHCH ETEESTIKDS TTQKAGLPSK NLTVSQNQSE EFYNGPNRNR LLLKSDEESD KVISWSCKQL FDISLFRNPF FYIFTWSFLL SQLAYFIPTF HLVARAKTLG IDIMDASYLV SVAGILETVS QIISGWVADQ NWIKKYHYHK SYLILCGITN LLAPLATTFP LLMTYTICFA IFAGGYLALI LPVLVDLCRN STVNRFLGLA SFFAGMAVLS GPPIAGWLYD YTQTYNGSFY FSGICYLLSS VSFFFVPLAE RWKNSLT
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