Monocarboxylate transporter 6 (SLC16A5)

About Monocarboxylate transporter 6

Monocarboxylate transporter 6 (SLC16A5) is a protein from Homo sapiens identified by UniProt accession O15375, 505 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Monocarboxylate transporter 6
UniProt accession	O15375
Gene	SLC16A5
Organism	Homo sapiens
Length	505 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.17
sex hormone-binding globulin measurement · score 0.03
neutrophil percentage of leukocytes · score 0.03
serum gamma-glutamyl transferase measurement · score 0.02
HbA1c measurement · score 0.02
clear cell renal carcinoma · score 0.02
neoplasm · score 0.02
prostate carcinoma · score 0.01
infection · score 0.01
infect · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15375-F1	alphafold	PREDICTED	80.49	—

Amino-acid sequence (505 residues)

MPQALERADG SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS ETSWFPSILT AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS HNLSQLYFTA GFITGLGMCF SFQSSITVLG FYFVRRRVLA NALASMGVSL GITLWPLLSR YLLENLGWRG TFLVFGGIFL HCCICGAIIR PVATSVAPET KECPPPPPET PALGCLAACG RTIQRHLAFD ILRHNTGYCV YILGVMWSVL GFPLPQVFLV PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF ASHRKYLFSL ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF QVLMDIVPMD QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM SSFFLISAAL FMGGSFYALQ KKEQGKQAVA ADALERDLFL EAKDGPGKQR SPEIMCQSSR QPRPAGVNKH LWGCPASSRT SHEWLLWPKA VLQAKQTALG WNSPT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards