Histone deacetylase 3 (HDAC3)

About Histone deacetylase 3

Histone deacetylase 3 (HDAC3) is a protein from Homo sapiens identified by UniProt accession O15379, 428 residues long. MolForge cross-references it against 0 known binders and 528 disease associations.

Target properties

Protein name	Histone deacetylase 3
UniProt accession	O15379
Gene	HDAC3
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (528)

Diseases linked to this target (Open Targets).

neoplasm · score 0.57
multiple myeloma · score 0.57
neurodegenerative disease · score 0.53
unspecified peripheral T-cell lymphoma · score 0.52
Cutaneous T-cell lymphoma · score 0.51
T-cell non-Hodgkin lymphoma · score 0.50
graft versus host disease · score 0.39
primary myelofibrosis · score 0.38
viral disease · score 0.38
lymphoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15379-F1	alphafold	PREDICTED	90.78	—

Amino-acid sequence (428 residues)

MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI NQVVDFYQPT CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP EENYSRPEAP NEFYDGDHDN DKESDVEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards