About Branched-chain-amino-acid aminotransferase, mitochondrial
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) is a protein
from Homo sapiens identified by UniProt accession
O15382, 392 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Branched-chain-amino-acid aminotransferase, mitochondrial |
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| UniProt accession | O15382 |
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| Gene | BCAT2 |
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| Organism | Homo sapiens |
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| Length | 392 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- hypervalinemia and hyperleucine-isoleucinemia · score 0.61
- valine measurement · score 0.33
- serum metabolite measurement · score 0.24
- neurodegenerative disease · score 0.24
- blood protein measurement · score 0.14
- branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid measurement · score 0.11
- neoplasm · score 0.09
- cancer · score 0.08
- bladder transitional cell carcinoma · score 0.07
- hypotrichosis simplex · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15382-F1 | alphafold | PREDICTED | 93.14 | — |
Amino-acid sequence (392 residues)
MAAAALGQIW ARKLLSVPWL LCGPRRYASS SFKAADLQLE MTQKPHKKPG PGEPLVFGKT FTDHMLMVEW NDKGWGQPRI QPFQNLTLHP ASSSLHYSLQ LFEGMKAFKG KDQQVRLFRP WLNMDRMLRS AMRLCLPSFD KLELLECIRR LIEVDKDWVP DAAGTSLYVR PVLIGNEPSL GVSQPTRALL FVILCPVGAY FPGGSVTPVS LLADPAFIRA WVGGVGNYKL GGNYGPTVLV QQEALKRGCE QVLWLYGPDH QLTEVGTMNI FVYWTHEDGV LELVTPPLNG VILPGVVRQS LLDMAQTWGE FRVVERTITM KQLLRALEEG RVREVFGSGT ACQVCPVHRI LYKDRNLHIP TMENGPELIL RFQKELKEIQ YGIRAHEWMF PV
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