About Sialic acid-binding Ig-like lectin 5
Sialic acid-binding Ig-like lectin 5 (SIGLEC5) is a protein
from Homo sapiens identified by UniProt accession
O15389, 551 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Sialic acid-binding Ig-like lectin 5 |
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| UniProt accession | O15389 |
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| Gene | SIGLEC5 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.39
- eosinophil count · score 0.38
- lymphocyte count · score 0.36
- mean corpuscular hemoglobin concentration · score 0.34
- monocyte count · score 0.32
- mean corpuscular volume · score 0.32
- eosinophil percentage of leukocytes · score 0.30
- periodontitis · score 0.28
- cerebrospinal fluid biomarker measurement · score 0.28
- systemic lupus erythematosus · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15389-F1 | alphafold | PREDICTED | 77.73 | — |
Amino-acid sequence (551 residues)
MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQMKRQGA QVTTERTVQL NVSYAPQTIT IFRNGIALEI LQNTSYLPVL EGQALRLLCD APSNPPAHLS WFQGSPALNA TPISNTGILE LRRVRSAEEG GFTCRAQHPL GFLQIFLNLS VYSLPQLLGP SCSWEAEGLH CRCSFRARPA PSLCWRLEEK PLEGNSSQGS FKVNSSSAGP WANSSLILHG GLSSDLKVSC KAWNIYGSQS GSVLLLQGRS NLGTGVVPAA LGGAGVMALL CICLCLIFFL IVKARRKQAA GRPEKMDDED PIMGTITSGS RKKPWPDSPG DQASPPGDAP PLEEQKELHY ASLSFSEMKS REPKDQEAPS TTEYSEIKTS K
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