Baculoviral IAP repeat-containing protein 5 (BIRC5)

About Baculoviral IAP repeat-containing protein 5

Baculoviral IAP repeat-containing protein 5 (BIRC5) is a protein from Homo sapiens identified by UniProt accession O15392, 142 residues long. MolForge cross-references it against 0 known binders and 804 disease associations.

Target properties

Protein name	Baculoviral IAP repeat-containing protein 5
UniProt accession	O15392
Gene	BIRC5
Organism	Homo sapiens
Length	142 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (804)

Diseases linked to this target (Open Targets).

endometrial cancer · score 0.27
gastric adenocarcinoma · score 0.25
urinary bladder cancer · score 0.23
non-small cell lung carcinoma · score 0.14
hepatocellular carcinoma · score 0.13
glioblastoma multiforme · score 0.13
acute myeloid leukemia · score 0.12
neoplasm · score 0.12
lung adenocarcinoma · score 0.12
cancer · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15392-F1	alphafold	PREDICTED	94.80	—

Amino-acid sequence (142 residues)

MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK KKEFEETAKK VRRAIEQLAA MD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards