About TOX high mobility group box family member 3
TOX high mobility group box family member 3 (TOX3) is a protein
from Homo sapiens identified by UniProt accession
O15405, 576 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | TOX high mobility group box family member 3 |
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| UniProt accession | O15405 |
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| Gene | TOX3 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- breast carcinoma · score 0.51
- hematocrit · score 0.42
- neuroticism measurement · score 0.42
- hemoglobin measurement · score 0.42
- cancer · score 0.41
- insomnia measurement · score 0.41
- cortical surface area measurement · score 0.41
- systolic blood pressure · score 0.40
- chronotype measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15405-F1 | alphafold | PREDICTED | 59.10 | — |
Amino-acid sequence (576 residues)
MDVRFYPAAA GDPASLDFAQ CLGYYGYSKF GNNNNYMNMA EANNAFFAAS EQTFHTPSLG DEEFEIPPIT PPPESDPALG MPDVLLPFQA LSDPLPSQGS EFTPQFPPQS LDLPSITISR NLVEQDGVLH SSGLHMDQSH TQVSQYRQDP SLIMRSIVHM TDAARSGVMP PAQLTTINQS QLSAQLGLNL GGASMPHTSP SPPASKSATP SPSSSINEED ADEANRAIGE KRAAPDSGKK PKTPKKKKKK DPNEPQKPVS AYALFFRDTQ AAIKGQNPNA TFGEVSKIVA SMWDSLGEEQ KQVYKRKTEA AKKEYLKALA AYRASLVSKA AAESAEAQTI RSVQQTLAST NLTSSLLLNT PLSQHGTVSA SPQTLQQSLP RSIAPKPLTM RLPMNQIVTS VTIAANMPSN IGAPLISSMG TTMVGSAPST QVSPSVQTQQ HQMQLQQQQQ QQQQQMQQMQ QQQLQQHQMH QQIQQQMQQQ HFQHHMQQHL QQQQQHLQQQ INQQQLQQQL QQRLQLQQLQ HMQHQSQPSP RQHSPVASQI TSPIPAIGSP QPASQQHQSQ IQSQTQTQVL SQVSIF
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