About Monocarboxylate transporter 4
Monocarboxylate transporter 4 (SLC16A3) is a protein
from Homo sapiens identified by UniProt accession
O15427, 465 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Monocarboxylate transporter 4 |
|---|
| UniProt accession | O15427 |
|---|
| Gene | SLC16A3 |
|---|
| Organism | Homo sapiens |
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| Length | 465 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (127)
Diseases linked to this target (Open Targets).
- body mass index · score 0.27
- glioblastoma multiforme · score 0.21
- non-small cell lung carcinoma · score 0.20
- blood urea nitrogen measurement · score 0.15
- neoplasm · score 0.11
- lung adenocarcinoma · score 0.10
- serum urea measurement · score 0.10
- nonpapillary renal cell carcinoma · score 0.09
- urinary bladder carcinoma · score 0.08
- body height · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15427-F1 | alphafold | PREDICTED | 83.60 | — |
Amino-acid sequence (465 residues)
MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF LILGGLLLNC CVCAALMRPL VVTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL GLFVPPVFVV SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF SMFFNGLADL AGSTAGDYGG LVVFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEVVHT PETSV
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