About High affinity copper uptake protein 1
High affinity copper uptake protein 1 (SLC31A1) is a protein
from Homo sapiens identified by UniProt accession
O15431, 190 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | High affinity copper uptake protein 1 |
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| UniProt accession | O15431 |
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| Gene | SLC31A1 |
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| Organism | Homo sapiens |
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| Length | 190 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (152)
Diseases linked to this target (Open Targets).
- neurodegeneration and seizures due to copper transport defect · score 0.51
- autosomal recessive non-syndromic intellectual disability · score 0.37
- Neurodevelopmental disorder · score 0.23
- epilepsy · score 0.18
- neoplasm · score 0.11
- cancer · score 0.10
- leukocyte count · score 0.08
- appendicular lean mass · score 0.08
- urinary bladder carcinoma · score 0.07
- neuroblastoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15431-F1 | alphafold | PREDICTED | 70.28 | — |
Amino-acid sequence (190 residues)
MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS IRYNSMPVPG PNGTILMETH KTVGQQMLSF PHLLQTVLHI IQVVISYFLM LIFMTYNGYL CIAVAAGAGT GYFLFSWKKA VVVDITEHCH
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