About Metallophosphoesterase domain-containing protein 1
Metallophosphoesterase domain-containing protein 1 (MPPED1) is a protein
from Homo sapiens identified by UniProt accession
O15442, 326 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Metallophosphoesterase domain-containing protein 1 |
|---|
| UniProt accession | O15442 |
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| Gene | MPPED1 |
|---|
| Organism | Homo sapiens |
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| Length | 326 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.33
- IGF-1 measurement · score 0.32
- protein measurement · score 0.32
- urate measurement · score 0.32
- bone density · score 0.32
- cortical surface area measurement · score 0.30
- brain measurement · score 0.16
- central nervous system cancer · score 0.04
- glioblastoma multiforme · score 0.03
- sleep measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15442-F1 | alphafold | PREDICTED | 88.52 | — |
Amino-acid sequence (326 residues)
MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY SSNPTQAFTF YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS RTDPIQMPYG DVLIHAGDFT ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN YENVQSLLTN CIYLQDSEVT VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD ILITHGPPLG FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV NASVCTVNYQ PVNPPIVIDL PTPRNS
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