About DNA-directed RNA polymerase I subunit RPA34
DNA-directed RNA polymerase I subunit RPA34 (POLR1G) is a protein
from Homo sapiens identified by UniProt accession
O15446, 510 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerase I subunit RPA34 |
|---|
| UniProt accession | O15446 |
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| Gene | POLR1G |
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| Organism | Homo sapiens |
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| Length | 510 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- apolipoprotein B measurement · score 0.30
- platelet count · score 0.28
- arterial stiffness measurement · score 0.21
- low density lipoprotein cholesterol measurement · score 0.10
- heel bone mineral density · score 0.05
- non-small cell lung carcinoma · score 0.03
- red color blindness · score 0.02
- neoplasm · score 0.02
- multiple myeloma · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15446-F1 | alphafold | PREDICTED | 55.88 | — |
Amino-acid sequence (510 residues)
MEEPQAGDAA RFSCPPNFTA KPPASESPRF SLEALTGPDT ELWLIQAPAD FAPECFNGRH VPLSGSQIVK GKLAGKRHRY RVLSSCPQAG EATLLAPSTE AGGGLTCASA PQGTLRILEG PQQSLSGSPL QPIPASPPPQ IPPGLRPRFC AFGGNPPVTG PRSALAPNLL TSGKKKKEMQ VTEAPVTQEA VNGHGALEVD MALGSPEMDV RKKKKKKNQQ LKEPEAAGPV GTEPTVETLE PLGVLFPSTT KKRKKPKGKE TFEPEDKTVK QEQINTEPLE DTVLSPTKKR KRQKGTEGME PEEGVTVESQ PQVKVEPLEE AIPLPPTKKR KKEKGQMAMM EPGTEAMEPV EPEMKPLESP GGTMAPQQPE GAKPQAQAAL AAPKKKTKKE KQQDATVEPE TEVVGPELPD DLEPQAAPTS TKKKKKKKER GHTVTEPIQP LEPELPGEGQ PEARATPGST KKRKKQSQES RMPETVPQEE MPGPPLNSES GEEAPTGRDK KRKQQQQQPV
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