Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)

About Prolyl 4-hydroxylase subunit alpha-2

Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) is a protein from Homo sapiens identified by UniProt accession O15460, 535 residues long. MolForge cross-references it against 0 known binders and 176 disease associations.

Target properties

Protein name	Prolyl 4-hydroxylase subunit alpha-2
UniProt accession	O15460
Gene	P4HA2
Organism	Homo sapiens
Length	535 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (176)

Diseases linked to this target (Open Targets).

Myopia · score 0.55
myopia · score 0.37
body height · score 0.34
neutrophil count · score 0.29
Crohn's disease · score 0.27
aspartate aminotransferase measurement · score 0.26
brain volume measurement · score 0.25
breast adenocarcinoma · score 0.23
brain measurement · score 0.22
mosquito bite reaction size measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15460-F1	alphafold	PREDICTED	89.40	—

Amino-acid sequence (535 residues)

MKLWVSALLM AWFGVLSCVQ AEFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG DYYHTVLWME QVLKQLDAGE EATTTKSQVL DYLSYAVFQL GDLHRALELT RRLLSLDPSH ERAGGNLRYF EQLLEEEREK TLTNQTEAEL ATPEGIYERP VDYLPERDVY ESLCRGEGVK LTPRRQKRLF CRYHHGNRAP QLLIAPFKEE DEWDSPHIVR YYDVMSDEEI ERIKEIAKPK LARATVRDPK TGVLTVASYR VSKSSWLEED DDPVVARVNR RMQHITGLTV KTAELLQVAN YGVGGQYEPH FDFSRNDERD TFKHLGTGNR VATFLNYMSD VEAGGATVFP DLGAAIWPKK GTAVFWYNLL RSGEGDYRTR HAACPVLVGC KWVSNKWFHE RGQEFLRPCG STEVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards