Melanoma-associated antigen B2 (MAGEB2)

About Melanoma-associated antigen B2

Melanoma-associated antigen B2 (MAGEB2) is a protein from Homo sapiens identified by UniProt accession O15479, 319 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Melanoma-associated antigen B2
UniProt accession	O15479
Gene	MAGEB2
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.05
neoplasm · score 0.04
colorectal adenocarcinoma · score 0.04
breast carcinoma · score 0.04
Systemic lupus erythematosus · score 0.04
Autoimmune polyendocrinopathy type 1 · score 0.03
Vitiligo · score 0.03
malignant peripheral nerve sheath tumor · score 0.03
laryngotracheoesophageal cleft · score 0.03
carcinoma of liver and intrahepatic biliary tract · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15479-F1	alphafold	PREDICTED	70.87	—

Amino-acid sequence (319 residues)

MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA SSSPAAGIPQ EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS TSTKSPSEDP LTRKSGSLVQ FLLYKYKIKK SVTKGEMLKI VGKRFREHFP EILKKASEGL SVVFGLELNK VNPNGHTYTF IDKVDLTDEE SLLSSWDFPR RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV FGEPWKLITK DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP CAFPTHYEEA LKDEEKAGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards