About Melanoma-associated antigen B3
Melanoma-associated antigen B3 (MAGEB3) is a protein
from Homo sapiens identified by UniProt accession
O15480, 346 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Melanoma-associated antigen B3 |
|---|
| UniProt accession | O15480 |
|---|
| Gene | MAGEB3 |
|---|
| Organism | Homo sapiens |
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| Length | 346 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (7)
Diseases linked to this target (Open Targets).
- melanoma · score 0.01
- breast cancer · score 0.01
- calf circumference measurement · score 0.01
- sarcoma · score 0.00
- hepatocellular carcinoma · score 0.00
- neoplasm · score 0.00
- lymph node metastatic carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15480-F1 | alphafold | PREDICTED | 74.29 | — |
Amino-acid sequence (346 residues)
MPRGQKSTLH AREKRQQTRG QTQDHQGAQI TATNKKKVSF SSPLILGATI QKKSAGRSRS ALKKPQRALS TTTSVDVSYK KSYKGANSKI EKKQSFSQGL SSTVQSRTDP LIMKTNMLVQ FLMEMYKMKK PIMKADMLKI VQKSHKNCFP EILKKASFNM EVVFGVDLKK VDSTKDSYVL VSKMDLPNNG TVTRGRGFPK TGLLLNLLGV IFMKGNCATE EKIWEFLNKM RIYDGKKHFI FGEPRKLITQ DLVKLKYLEY RQVPNSNPAR YEFLWGPRAH AETSKMKVLE FWAKVNKTVP SAFQFWYEEA LRDEEERVQA AAMLNDGSSA MGRKCSKAKA SSSSHA
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