Melanoma-associated antigen B4 (MAGEB4)

About Melanoma-associated antigen B4

Melanoma-associated antigen B4 (MAGEB4) is a protein from Homo sapiens identified by UniProt accession O15481, 346 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Melanoma-associated antigen B4
UniProt accession	O15481
Gene	MAGEB4
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.15
tarsal-carpal coalition syndrome · score 0.03
azoospermia · score 0.02
cancer · score 0.01
Azoospermia · score 0.01
Transitional Cell Carcinoma · score 0.01
breast cancer · score 0.01
neoplasm · score 0.01
urinary bladder carcinoma · score 0.00
male infertility · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15481-F1	alphafold	PREDICTED	73.94	—

Amino-acid sequence (346 residues)

MPRGQKSKLR AREKRQRTRG QTQDLKVGQP TAAEKEESPS SSSSVLRDTA SSSLAFGIPQ EPQREPPTTS AAAAMSCTGS DKGDESQDEE NASSSQASTS TERSLKDSLT RKTKMLVQFL LYKYKMKEPT TKAEMLKIIS KKYKEHFPEI FRKVSQRTEL VFGLALKEVN PTTHSYILVS MLGPNDGNQS SAWTLPRNGL LMPLLSVIFL NGNCAREEEI WEFLNMLGIY DGKRHLIFGE PRKLITQDLV QEKYLEYQQV PNSDPPRYQF LWGPRAHAET SKMKVLEFLA KVNDTTPNNF PLLYEEALRD EEERAGARPR VAARRGTTAM TSAYSRATSS SSSQPM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards