Glycogenin-2 (GYG2)

About Glycogenin-2

Glycogenin-2 (GYG2) is a protein from Homo sapiens identified by UniProt accession O15488, 501 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Glycogenin-2
UniProt accession	O15488
Gene	GYG2
Organism	Homo sapiens
Length	501 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

disorder of glycogen metabolism · score 0.37
acute myeloid leukemia · score 0.22
low grade glioma · score 0.18
head and neck squamous cell carcinoma · score 0.13
primary ovarian insufficiency · score 0.12
Abnormality of neuronal migration · score 0.11
Barrett's esophagus · score 0.05
colorectal adenocarcinoma · score 0.04
esophageal adenocarcinoma · score 0.04
cancer · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15488-F1	alphafold	PREDICTED	70.93	—

Amino-acid sequence (501 residues)

MSETEFHHGA QAGLELLRSS NSPTSASQSA GMTVTDQAFV TLATNDIYCQ GALVLGQSLR RHRLTRKLVV LITPQVSSLL RVILSKVFDE VIEVNLIDSA DYIHLAFLKR PELGLTLTKL HCWTLTHYSK CVFLDADTLV LSNVDELFDR GEFSAAPDPG WPDCFNSGVF VFQPSLHTHK LLLQHAMEHG SFDGADQGLL NSFFRNWSTT DIHKHLPFIY NLSSNTMYTY SPAFKQFGSS AKVVHFLGSM KPWNYKYNPQ SGSVLEQGSA SSSQHQAAFL HLWWTVYQNN VLPLYKSVQA GEARASPGHT LCHSDVGGPC ADSASGVGEP CENSTPSAGV PCANSPLGSN QPAQGLPEPT QIVDETLSLP EGRRSEDMIA CPETETPAVI TCDPLSQPSP QPADFTETET ILQPANKVES VSSEETFEPS QELPAEALRD PSLQDALEVD LAVSVSQISI EEKVKELSPE EERRKWEEGR IDYMGKDAFA RIQEKLDRFL Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards