Group 10 secretory phospholipase A2 (PLA2G10)

About Group 10 secretory phospholipase A2

Group 10 secretory phospholipase A2 (PLA2G10) is a protein from Homo sapiens identified by UniProt accession O15496, 165 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.

Target properties

Protein name	Group 10 secretory phospholipase A2
UniProt accession	O15496
Gene	PLA2G10
Organism	Homo sapiens
Length	165 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (295)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
acute coronary syndrome · score 0.15
coronary artery disease · score 0.10
Romano-Ward syndrome · score 0.07
Familial short QT syndrome · score 0.07
infection · score 0.06
infect · score 0.06
Barrett's esophagus · score 0.06
hypertrophic cardiomyopathy · score 0.06
Familial progressive cardiac conduction defect · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15496-F1	alphafold	PREDICTED	88.01	—

Amino-acid sequence (165 residues)

MGPLPVCLPI MLLLLLPSLL LLLLLPGPGS GEASRILRVH RRGILELAGT VGCVGPRTPI AYMKYGCFCG LGGHGQPRDA IDWCCHGHDC CYTRAEEAGC SPKTERYSWQ CVNQSVLCGP AENKCQELLC KCDQEIANCL AQTEYNLKYL FYPQFLCEPD SPKCD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards