Insulin-induced gene 1 protein (INSIG1)

About Insulin-induced gene 1 protein

Insulin-induced gene 1 protein (INSIG1) is a protein from Homo sapiens identified by UniProt accession O15503, 277 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Insulin-induced gene 1 protein
UniProt accession	O15503
Gene	INSIG1
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
hair colour measurement · score 0.29
visual perception measurement · score 0.29
PHF-tau measurement · score 0.28
coronary artery disease · score 0.27
neuroticism measurement · score 0.27
gut microbiome measurement · score 0.27
total cholesterol measurement · score 0.27
angina pectoris · score 0.27
low density lipoprotein cholesterol measurement · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15503-F1	alphafold	PREDICTED	68.24	—

Amino-acid sequence (277 residues)

MPRLHDHFWS CSCAHSARRR GPPRASAAGL AAKVGEMINV SVSGPSLLAA HGAPDADPAP RGRSAAMSGP EPGSPYPNTW HHRLLQRSLV LFSVGVVLAL VLNLLQIQRN VTLFPEEVIA TIFSSAWWVP PCCGTAAAVV GLLYPCIDSH LGEPHKFKRE WASVMRCIAV FVGINHASAK LDFANNVQLS LTLAALSLGL WWTFDRSRSG LGLGITIAFL ATLITQFLVY NGVYQYTSPD FLYIRSWLPC IFFSGGVTVG NIGRQLAMGV PEKPHSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards