Nucleoporin NUP42 (NUP42)

About Nucleoporin NUP42

Nucleoporin NUP42 (NUP42) is a protein from Homo sapiens identified by UniProt accession O15504, 423 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Nucleoporin NUP42
UniProt accession	O15504
Gene	NUP42
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

influenza · score 0.54
HIV infection · score 0.54
viral disease · score 0.53
Histiocytosis · score 0.37
COVID-19 · score 0.37
blood protein measurement · score 0.22
transmembrane glycoprotein NMB measurement · score 0.21
Parkinson disease · score 0.11
electrocardiography · score 0.11
body height · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15504-F1	alphafold	PREDICTED	55.35	—

Amino-acid sequence (423 residues)

MAICQFFLQG RCRFGDRCWN EHPGARGAGG GRQQPQQQPS GNNRRGWNTT SQRYSNVIQP SSFSKSTPWG GSRDQEKPYF SSFDSGASTN RKEGFGLSEN PFASLSPDEQ KDEKKLLEGI VKDMEVWESS GQWMFSVYSP VKKKPNISGF TDISPEELRL EYHNFLTSNN LQSYLNSVQR LINQWRNRVN ELKSLNISTK VALLSDVKDG VNQAAPAFGF GSSQAATFMS PGFPVNNSSS DNAQNFSFKT NSGFAAASSG SPAGFGSSPA FGAAASTSSG ISTSAPAFGF GKPEVTSAAS FSFKSPAASS FGSPGFSGLP ASLATGPVRA PVAPAFGGGS SVAGFGSPGS HSHTAFSKPS SDTFGNSSIS TSLSASSSII ATDNVLFTPR DKLTVEELEQ FQSKKFTLGK IPLKPPPLEL LNV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards