Actin-related protein 2/3 complex subunit 5 (ARPC5)

About Actin-related protein 2/3 complex subunit 5

Actin-related protein 2/3 complex subunit 5 (ARPC5) is a protein from Homo sapiens identified by UniProt accession O15511, 151 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Actin-related protein 2/3 complex subunit 5
UniProt accession	O15511
Gene	ARPC5
Organism	Homo sapiens
Length	151 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
combined immunodeficiency · score 0.37
Combined immunodeficiency · score 0.37
cutaneous Leishmaniasis · score 0.37
neuroinflammatory disorder · score 0.32
genetic disorder · score 0.18
chronotype measurement · score 0.10
Miyoshi myopathy · score 0.09
hepatocellular carcinoma · score 0.08
neoplasm · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15511-F1	alphafold	PREDICTED	92.20	—

Amino-acid sequence (151 residues)

MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards