DNA-directed RNA polymerase II subunit RPB4 (POLR2D)

About DNA-directed RNA polymerase II subunit RPB4

DNA-directed RNA polymerase II subunit RPB4 (POLR2D) is a protein from Homo sapiens identified by UniProt accession O15514, 142 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase II subunit RPB4
UniProt accession	O15514
Gene	POLR2D
Organism	Homo sapiens
Length	142 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
influenza · score 0.37
acrocephalosyndactyly · score 0.37
lung adenocarcinoma · score 0.27
high density lipoprotein cholesterol measurement · score 0.27
apolipoprotein A 1 measurement · score 0.26
cutaneous melanoma · score 0.24
squamous cell lung carcinoma · score 0.18
monocyte count · score 0.12
urinary bladder cancer · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15514-F1	alphafold	PREDICTED	91.26	—

Amino-acid sequence (142 residues)

MAAGGSDPRA GDVEEDASQL IFPKEFETAE TLLNSEVHML LEHRKQQNES AEDEQELSEV FMKTLNYTAR FSRFKNRETI ASVRSLLLQK KLHKFELACL ANLCPETAEE SKALIPSLEG RFEDEELQQI LDDIQTKRSF QY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards