CASP8 and FADD-like apoptosis regulator (CFLAR)

About CASP8 and FADD-like apoptosis regulator

CASP8 and FADD-like apoptosis regulator (CFLAR) is a protein from Homo sapiens identified by UniProt accession O15519, 480 residues long. MolForge cross-references it against 0 known binders and 332 disease associations.

Target properties

Protein name	CASP8 and FADD-like apoptosis regulator
UniProt accession	O15519
Gene	CFLAR
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (332)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
mean corpuscular volume · score 0.29
platelet count · score 0.29
total blood protein measurement · score 0.29
chronic lymphocytic leukemia · score 0.26
body height · score 0.23
mean reticulocyte volume · score 0.21
rheumatoid arthritis · score 0.19
head and neck squamous cell carcinoma · score 0.18
mean corpuscular hemoglobin concentration · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15519-F1	alphafold	PREDICTED	78.33	—

Amino-acid sequence (480 residues)

MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards