About Homeobox protein Nkx-2.8
Homeobox protein Nkx-2.8 (NKX2-8) is a protein
from Homo sapiens identified by UniProt accession
O15522, 239 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Homeobox protein Nkx-2.8 |
|---|
| UniProt accession | O15522 |
|---|
| Gene | NKX2-8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- intelligence · score 0.34
- mathematical ability · score 0.29
- self reported educational attainment · score 0.28
- verbal-numerical reasoning measurement · score 0.24
- age at menarche · score 0.13
- cognitive function measurement · score 0.08
- body height · score 0.08
- ulcerative colitis · score 0.07
- hepatocellular carcinoma · score 0.07
- neoplasm · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15522-F1 | alphafold | PREDICTED | 66.42 | — |
Amino-acid sequence (239 residues)
MATSGRLSFT VRSLLDLPEQ DAQHLPRREP EPRAPQPDPC AAWLDSERGH YPSSDESSLE TSPPDSSQRP SARPASPGSD AEKRKKRRVL FSKAQTLELE RRFRQQRYLS APEREQLASL LRLTPTQVKI WFQNHRYKLK RARAPGAAES PDLAASAELH AAPGLLRRVV VPVLVRDGQP CGGGGGGEVG TAAAQEKCGA PPAAACPLPG YPAFGPGSAL GLFPAYQHLA SPALVSWNW
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