About ATP-dependent RNA helicase DDX3Y
ATP-dependent RNA helicase DDX3Y (DDX3Y) is a protein
from Homo sapiens identified by UniProt accession
O15523, 660 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase DDX3Y |
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| UniProt accession | O15523 |
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| Gene | DDX3Y |
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| Organism | Homo sapiens |
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| Length | 660 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.38
- amyotrophic lateral sclerosis · score 0.07
- Ataxia-telangiectasia · score 0.06
- breast carcinoma · score 0.05
- multiple sclerosis · score 0.05
- Adams-Oliver syndrome · score 0.04
- Azoospermia · score 0.02
- cystic fibrosis · score 0.02
- male infertility · score 0.02
- glioblastoma multiforme · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15523-F1 | alphafold | PREDICTED | 72.06 | — |
Amino-acid sequence (660 residues)
MSHVVVKNDP ELDQQLANLD LNSEKQSGGA STASKGRYIP PHLRNREASK GFHDKDSSGW SCSKDKDAYS SFGSRDSRGK PGYFSERGSG SRGRFDDRGR SDYDGIGNRE RPGFGRFERS GHSRWCDKSV EDDWSKPLPP SERLEQELFS GGNTGINFEK YDDIPVEATG SNCPPHIENF SDIDMGEIIM GNIELTRYTR PTPVQKHAIP IIKGKRDLMA CAQTGSGKTA AFLLPILSQI YTDGPGEALK AVKENGRYGR RKQYPISLVL APTRELAVQI YEEARKFSYR SRVRPCVVYG GADIGQQIRD LERGCHLLVA TPGRLVDMME RGKIGLDFCK YLVLDEADRM LDMGFEPQIR RIVEQDTMPP KGVRHTMMFS ATFPKEIQML ARDFLDEYIF LAVGRVGSTS ENITQKVVWV EDLDKRSFLL DILGATGSDS LTLVFVETKK GADSLEDFLY HEGYACTSIH GDRSQRDREE ALHQFRSGKS PILVATAVAA RGLDISNVRH VINFDLPSDI EEYVHRIGRT GRVGNLGLAT SFFNEKNMNI TKDLLDLLVE AKQEVPSWLE NMAYEHHYKG GSRGRSKSNR FSGGFGARDY RQSSGSSSSG FGASRGSSSR SGGGGYGNSR GFGGGGYGGF YNSDGYGGNY NSQGVDWWGN
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