About Transcription factor MafG
Transcription factor MafG (MAFG) is a protein
from Homo sapiens identified by UniProt accession
O15525, 162 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Transcription factor MafG |
|---|
| UniProt accession | O15525 |
|---|
| Gene | MAFG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 162 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- esophageal cancer · score 0.15
- hereditary breast ovarian cancer syndrome · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
- hepatocellular carcinoma · score 0.10
- breast cancer · score 0.10
- esophageal squamous cell carcinoma · score 0.09
- neoplasm · score 0.08
- urinary bladder carcinoma · score 0.08
- melanoma · score 0.08
- glioblastoma multiforme · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15525-F1 | alphafold | PREDICTED | 79.46 | — |
Amino-acid sequence (162 residues)
MTTPNKGNKA LKVKREPGEN GTSLTDEELV TMSVRELNQH LRGLSKEEIV QLKQRRRTLK NRGYAASCRV KRVTQKEELE KQKAELQQEV EKLASENASM KLELDALRSK YEALQTFART VARSPVAPAR GPLAAGLGPL VPGKVAATSV ITIVKSKTDA RS
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