N-glycosylase/DNA lyase (OGG1)

About N-glycosylase/DNA lyase

N-glycosylase/DNA lyase (OGG1) is a protein from Homo sapiens identified by UniProt accession O15527, 345 residues long. MolForge cross-references it against 0 known binders and 359 disease associations.

Target properties

Protein name	N-glycosylase/DNA lyase
UniProt accession	O15527
Gene	OGG1
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (359)

Diseases linked to this target (Open Targets).

cancer · score 0.57
Alzheimer disease · score 0.46
clear cell renal carcinoma · score 0.34
breast adenocarcinoma · score 0.18
neurodegenerative disease · score 0.11
hepatocellular carcinoma · score 0.10
non-small cell lung carcinoma · score 0.10
neoplasm · score 0.10
urinary bladder carcinoma · score 0.09
head and neck squamous cell carcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15527-F1	alphafold	PREDICTED	92.34	—

Amino-acid sequence (345 residues)

MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards