G-protein coupled receptor 42 (GPR42)

About G-protein coupled receptor 42

G-protein coupled receptor 42 (GPR42) is a protein from Homo sapiens identified by UniProt accession O15529, 346 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	G-protein coupled receptor 42
UniProt accession	O15529
Gene	GPR42
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

MODY · score 0.08
hyperinsulinism due to INSR deficiency · score 0.07
hyperinsulinism due to glucokinase deficiency · score 0.06
hyperproinsulinemia · score 0.06
exercise-induced hyperinsulinism · score 0.05
diabetes mellitus, transient neonatal, 2 · score 0.05
hyperinsulinemic hypoglycemia, familial, 4 · score 0.04
hepatorenocardiac degenerative fibrosis · score 0.04
hyperinsulinemic hypoglycemia, familial, 1 · score 0.04
kidney disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15529-F1	alphafold	PREDICTED	87.04	—

Amino-acid sequence (346 residues)

MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLRCRPVAV DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI LLPVRLEMAV VLFVVPLIIT SYCYSRLVWI LGRGGSHRRQ RRVAGLVAAT LLNFLVCFGP YNVSHVVGYI CGESPVWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards