About 3-phosphoinositide-dependent protein kinase 1
3-phosphoinositide-dependent protein kinase 1 (PDPK1) is a protein
from Homo sapiens identified by UniProt accession
O15530, 556 residues long.
MolForge cross-references it against 0 known binders and
200 disease associations.
Target properties
| Protein name | 3-phosphoinositide-dependent protein kinase 1 |
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| UniProt accession | O15530 |
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| Gene | PDPK1 |
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| Organism | Homo sapiens |
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| Length | 556 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (200)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- cancer · score 0.38
- breast carcinoma · score 0.37
- COVID-19 · score 0.37
- ovarian carcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- severe acute respiratory syndrome · score 0.37
- ovarian cancer · score 0.31
- endometrial cancer · score 0.29
- head and neck squamous cell carcinoma · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15530-F1 | alphafold | PREDICTED | 78.75 | — |
Amino-acid sequence (556 residues)
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ EVWRQRYQSH PDAAVQ
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