Tapasin (TAPBP)

About Tapasin

Tapasin (TAPBP) is a protein from Homo sapiens identified by UniProt accession O15533, 448 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Tapasin
UniProt accession	O15533
Gene	TAPBP
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

Immunodeficiency by defective expression of HLA class 1 · score 0.62
MHC class I deficiency · score 0.49
age at menopause · score 0.10
neoplasm · score 0.09
malaria · score 0.07
body mass index · score 0.06
severe combined immunodeficiency due to CTPS1 deficiency · score 0.05
immunodeficiency 18 · score 0.05
severe combined immunodeficiency due to CARD11 deficiency · score 0.05
reticular dysgenesis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O15533-F1	alphafold	PREDICTED	87.06	—

Amino-acid sequence (448 residues)

MKSLSLLLAV ALGLATAVSA GPAVIECWFV EDASGKGLAK RPGALLLRQG PGEPPPRPDL DPELYLSVHD PAGALQAAFR RYPRGAPAPH CEMSRFVPLP ASAKWASGLT PAQNCPRALD GAWLMVSISS PVLSLSSLLR PQPEPQQEPV LITMATVVLT VLTHTPAPRV RLGQDALLDL SFAYMPPTSE AASSLAPGPP PFGLEWRRQH LGKGHLLLAA TPGLNGQMPA AQEGAVAFAA WDDDEPWGPW TGNGTFWLPT VQPFQEGTYL ATIHLPYLQG QVTLELAVYK PPKVSLMPAT LARAAPGEAP PELLCLVSHF YPSGGLEVEW ELRGGPGGRS QKAEGQRWLS ALRHHSDGSV SLSGHLQPPP VTTEQHGARY ACRIHHPSLP ASGRSAEVTL EVAGLSGPSL EDSVGLFLSA FLLLGLFKAL GWAAVYLSTC KDSKKKAE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards